Research Sheds New Light on Epilepsy
Pioneering research using human brain tissue removed from people suffering from epilepsy has opened the door to new treatments for the disease.
Scientists at Newcastle University have for the first time been able to record spontaneous epileptic activity in brain tissue that has been removed from patients undergoing neurosurgery. Led by Newcastle University’s Dr Mark Cunningham, the research has revealed that a particular type of brain wave pattern associated with epilepsy caused by electrical connections between nerve cells in the brain rather than chemical ones. This means the traditional drugs are useless to them.
Published today in the Proceedings of the National Academy of Science (PNAS), Dr Cunningham said the findings marked a huge step forward in our understanding of a disease which affects an estimated 45 million people worldwide. “Until now we have only been able to mimic epilepsy using experimental animal models but this can never give you a true picture of what is actually going on inside the human brain in epilepsy,” explained Cr Cunningham who is based in Newcastle University’s Institute of Neuroscience.
